Accordingly, MSNs modified with imaging agents have been developed. To assess the drug efficacy and toxicity of drug carriers, it is essential to monitor the localization of the drug carrier. 3 Since controlled release of drugs from the pores of MSNs results in prolonged drug efficacy, MSNs serve as ideal materials for drug delivery. 2 Among these nanocarriers, mesoporous silica nanoparticles (MSNs) have attracted significant attention owing to their attractive properties such as extremely large surface areas (1000 m 2 g –1), tunable pore sizes (1.5–10 nm), and ease of functionalization via various synthetic approaches. 1 Toward this end, various nanoparticle-based drug carriers such as liposomes, polymers, and inorganic materials have been developed. Our results suggested that MSNs may serve as promising 19F MRI-traceable drug carriers for application in cancer therapy and bio-imaging.Įfficient delivery of drugs to diseased tissues is a major goal in the field of drug delivery in an effort to reduce adverse effects. The release rates of DOX from the nanoparticles increased under acidic conditions, and were favorable for controlled drug release to cancer cells. An anticancer drug (doxorubicin, DOX) was loaded in the pores of folate-functionalized MSNs for intracellular drug delivery. Furthermore, we demonstrated targeted drug delivery and cellular imaging by the conjugation of nanoparticles with folic acid. This drug delivery system facilitated the monitoring of the biodistribution of the drug carrier by dual modal imaging (NIR/ 19F MRI). The nanoparticles were labeled with fluorescent dyes and functionalized with small molecule-based ligands for active targeting. In this study, a novel drug delivery carrier based on MSNs, which encapsulated highly sensitive 19F magnetic resonance imaging (MRI) contrast agents inside MSNs, was developed. In particular, controlled release of drugs from MSN pores constitutes one of the superior features of MSNs. Multifunctional mesoporous silica nanoparticles (MSNs) are good candidates for multimodal applications in drug delivery, bioimaging, and cell targeting.
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